Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection
نویسندگان
چکیده
منابع مشابه
Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★
In recent years, chronic immune activation and systemic inflammation have emerged as hallmarks of HIV disease progression and mortality. Several studies indicate that soluble inflammatory biomarkers (sCD14, IL-6, IL-8, CRP and hyaluronic acid), as well as surface markers of T-cell activation (CD38, HLA-DR) independently predict progression to AIDS and mortality in HIV-infected individuals. Whil...
متن کاملTuberculosis/hiv Co-infection
Tuberculosis (TB) and human immunodeficiency virus/acquired immune deficiency syndrome (HIV/ AIDS) constitute the main burden of infectious disease in resource-limited countries. Estimates by the World Health Orgnisation (WHO) indicate that there are more than nine million new active cases of TB and close to two million deaths per year and 2.6 million new cases of HIV infection and 1.8 million ...
متن کاملImpact of monotherapy on HIV-1 reservoir, immune activation, and co-infection with Epstein-Barr virus
OBJECTIVES Although monotherapy (mART) effectiveness in maintaining viral suppression and CD4 cell count has been extensively examined in HIV-1-infected patients, its impact on HIV-1 reservoir, immune activation, microbial translocation and co-infection with Epstein-Barr Virus (EBV) is unclear. METHODS This retrospective study involved 32 patients who switched to mART; patients were studied a...
متن کاملImmune response during HIV and tuberculosis co-infection.
Laboratório de AIDS e Imunologia Molecular, Departamento de Imunologia, Instituto Oswaldo Cruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brasil *Laboratório Multidisciplinar de Pesquisa **Serviço de Pneumologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, RJ, Brasil ***Beatrice and Samuel A Seaver Laboratory, Division of Hematology-Oncology ****D...
متن کاملCoincident Helminth Infection Modulates Systemic Inflammation and Immune Activation in Active Pulmonary Tuberculosis
BACKGROUND Helminth infections are known to modulate innate and adaptive immune responses in active and latent tuberculosis (TB). However, the role of helminth infections in modulating responses associated with inflammation and immune activation (reflecting disease activity and/or severity) in TB is not known. METHODOLOGY We measured markers of inflammation and immune activation in active pul...
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ژورنال
عنوان ژورنال: Clinical and Experimental Immunology
سال: 1996
ISSN: 0009-9104,1365-2249
DOI: 10.1046/j.1365-2249.1996.907600.x